TENS – transkutan elektrisk neurostimulation kan have effekt ved nogle akutte og kroniske smertetilstande.Man starter oftest den smertestillende behandling med et svagt virkende middel, hvis ikke smerterne allerede er blevet stærke.Hvis TCA har været forsøgt i fuld dosis uden effekt er det teoretisk mindre sandsynligt, at SNRI vil have effekt.
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